Systemic lupus erythematosus and risk of osteoporosisArticles

P. Masaryk, A. Letkovská, J. Rovensky, J. Lukáč

Clin Osteol 2004; 9(2): 39-43

Autors review relationship between systemic lupus erythematosus (SLE) and osteoporosis which has been studied very intensively in last years. Initial­ ly, an inflammatory nature of osteoporosis was expected, similar to the rheumatoid arthritis. Many studies of bone density and bone metabolism have yielded controversial results and do not enable conclusion about nature of osteoporosis in SLE. Despite it only one study to this date confirms that pa­ tients with SLE have 5-times higher risk of fracture. No new risk factors specific for SLE have been found. High prevalence of fracture in SLE could be due to changes in hormonal status, seriousness of illness,...

Densitometry: most common errors and artefactsArticles

V. Vyskočil

Clin Osteol 2004; 9(2): 44-53

The author discusses double-photon densitometry, the most accurate and sensitive method of establishing the content of minerals in the skeleton and of monitoring its changes. He describes the most frequent errors and artefacts, which can substantially affect the interpretation of results and even render them completely useless. Besides degenerative changes during the aging of the body we find calcifications and anatomical and other skeletal changes connected with some diseases. Artefacts that are not frequently mentioned include errors in positioning or errors of the operator or of the la­ boratory assistant or nurse carrying out the actual examination....

The significance of subchondral bone in the pathogenesis of osteoarthritisArticles

L. Šenolt, K. Pavelka

Clin Osteol 2004; 9(2): 54-58

In this paper the authors summarise the role of subchondral bone in the destruction of articular cartilage and initiation or progression of osteoarthri­ tis. Osteoarthritis is characterised by progressive articular cartilage loss and new bone formation, sclerosis of subchondral bone and osteophytes, on the other hand. Subchondral bone stiffness play probably not such an important role in the mechanism of cartilage deterioration as proposed earlier. In the light of new data, bone microcraks, neovascularization and osteoblasts produced eicosanoids, cytokines, proteolytic enzymes and growth factors could contribute to the abnormal cartilage metabolism...

New materials for implants - biological reaction to implantsInformations

M. Adam, M. Petrtýl, K. Balík, V. Pešáková, H. Hulejová, Z. Klézl

Clin Osteol 2004; 9(2): 59-66

In order to accelerate biofixation, tested implants were impregnated with a copolymer of collagen with proteoglycan. Additionally, we tested polyethy­ lene (PE) and C-C-composite. We evaluated their biocompatibility on cell cultures of fibroblasts and investigated the reactions of neighbouring tissues to the implantation of these materials into the subcutis of laboratory sewer rats and paraosseally on the femur of farmyard pigs (Sus domesticus). We prepared polyethelene with either a hydrophobic or hydrophilic su they were coated with a film of the copolymer collagen-proteoglycan. We tested in vitro, how these materials affected cellular proliferation...

6th Conference on Secondary OsteoporosisInformations

S. Kutilek

Clin Osteol 2004; 9(2): 67

IOF World Congress on Osteoporosis, Rio de Janeiro, Brasil, May 14th-18th, 2004Informations

S. Kutílek, M. Bayer

Clin Osteol 2004; 9(2): 68

CorrectionInformations

Clin Osteol 2004; 9(2): 69

Abstracts from abroadLiterature

Clin Osteol 2004; 9(2): 70-71

Congress announcementsInformations

Clin Osteol 2004; 9(2): 72