Clin Osteol 2004; 9(2): 39-43

Systemic lupus erythematosus and risk of osteoporosisArticles

P. Masaryk, A. Letkovská, J. Rovensky, J. Lukáč

Autors review relationship between systemic lupus erythematosus (SLE) and osteoporosis which has been studied very intensively in last years. Initial­ ly, an inflammatory nature of osteoporosis was expected, similar to the rheumatoid arthritis. Many studies of bone density and bone metabolism have yielded controversial results and do not enable conclusion about nature of osteoporosis in SLE. Despite it only one study to this date confirms that pa­ tients with SLE have 5-times higher risk of fracture. No new risk factors specific for SLE have been found. High prevalence of fracture in SLE could be due to changes in hormonal status, seriousness of illness, organ complications (mainly renal) and with therapy (mainly corticoids).

Keywords: lupus erythematosus, osteoporosis.

Published: December 11, 2004  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Masaryk P, Letkovská A, Rovensky J, Lukáč J. Systemic lupus erythematosus and risk of osteoporosis. Osteologický bulletin. 2004;9(2):39-43.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Dostál C. Systémový lupus erythematodes. In: Rovenský J, Pavelka K, (eds). Kli­ nická reumatológia. Martin, Osveta, 2000:275-305.
    2. Mills JA Systemic lupus erythematosus. N Engl J Med 1994;330:1871-1879. Go to original source...
    3. Mikulecký M, Rovenský J, Žitňan D, et al. Prežívanie pacientov so systémovým lupus erythematosus, nepublikované dáta.
    4. Swaak AJG, van den Brink HG, Smeenk RIT, et al. Systemic lupus erythemato­ sus: clinical features in patients with a disease duration of over 10 years, first eva­ luation. Rheumatology 1999;38:953-958. Go to original source...
    5. Navarro MA, Vidaller A, Ortola JB, et al. Salivary testosteron levels in women with systemic lupus erythematosus. Arthritis Rheum 1992;35:557-559. Go to original source...
    6. Jungers P, Nahoul K, Pelissier C, et al. Low plasma androgens in women with active or quiescent systemic lupus erythematosus. Arthritis Rheum 1982; 25:454-457. Go to original source...
    7. Mok CC, Lau CS. Profile of sex hormones in male patients with systemic lupus erythematosus. Lupus 2000;9:252-257. Go to original source...
    8. Wilder RL, Elenkov ITJ. Hormonal regulation of tumor necrosis factor-alpha, in­ terleukin-12 and interleukin-10 production by activated macrophages. A diseasesmodifying mechanism in rheumatoid arthritis and systemic lupus erythematosus? Ann N Y Acad Sci 1999;876:14-31 Go to original source...
    9. Lahita RG. Pohlavné hormóny a ochorenia pohybového aparátu. In: Rovenský J. a kol: Reumatológia v teórii a praxi IV, Martin, Osveta,1996:144-150.
    10. Lahita RG. The role of sex hormones in systemic lupus erythematosus. Curr Opin Rheumatol 1999;11:352-356. Go to original source...
    11. Lahita RG, Bradlow HL, Kunkel HG, Fishman J. Alteration of estrogen metabo­ lism in systemic lupus erythematosus. Arthritis Rheum 1979;22:1195-1198. Go to original source...
    12. Lahita RG, Bradlow HL, Ginzler E, et al. Low plasma androgens in women with systemic lupus erythematosus. Arthritis Rheum 1987;30:241-248. Go to original source...
    13. Navarro MA, Formiga F, Blanco A, et al. PDN-21 in premenopausal women with systemic lupus erythematosus treated with glucocorticoids. J Rheumatol 1995;22:2238-2240.
    14. Ramsey-Goldman R, Dunn J, Huang CF, el al. Frequency of fractures in women with systemic lupus erythematosus. Arthritis Rheum 1999;42:882-890. Go to original source...
    15. Ramsey-Goldman R, Manzi S. Association of osteoporosis and cardiovascular di­ sease in women with systemic lupus erythematosus. Arthritis Rheum 2001;44:2338-2341. Go to original source...
    16. Dykman TR, Gluck OS, Murphy WA, et al. Evaluation of factors associated with glucocorticoid-induced osteopenia in patients with rheumatic diseases. Arthritis Rheum 1985;28:361-368. Go to original source...
    17. Kalla AA, Meyers OL, Parkyn ND, Kotze TJ. Osteoporosis screening-radiogrammetry revisited. Brit J Rheumatol 1989;28:511-517. Go to original source...
    18. Dhillon VB, Davies MC, Hall ML, et al. Assessment of the effect of oral corti­ costeroids on bone mineral density in systemic lupus erythematosus: a prelimina­ ry study with dual energy x ray absorptiometry. Ann Rheum Diss 1990;49:624-626. Go to original source...
    19. Kalla AA, Fataar AB, Jessop SJ, Bewerunge L. Loss of trabecular bone mineral density in systemic lupus erythematosus. Arthritis Rheum 1993;36:1726-1734 Go to original source...
    20. Pons F, Pteris P, Gaunabens N, et al. The efect of systemic lupus erythematosus and long-term steroid therapy on bone mass in pre-menopausal women. Brit J Rheumatol 1995;34:742-746. Go to original source...
    21. Formiga F, Moga I, Nolla JM, el al. Loss of bone mineral density in premenopau­ sal women with systemic lupus erythematosus. Ann Rheum Diss 1995;54:274-276. Go to original source...
    22. Sels F, Dequecker J, Westhovens R, et al. Bone mineral density in systemic lupus erythematosus. Rheumatology in Europe 1995;24:353.
    23. Houssiau FA, Lefebre C, Depresseux G, et al. Trabecular and cortical bone loss in systemic lupus erythematosus. Brit J Rheumatol 1996;35:244-247. Go to original source...
    24. Sels F, Dequecker J, Verwilghen J, Mbuyi-Muamba JM. SLE and osteoporosis: dependence and/or independence on glucocorticoids. Lupus 1996;5:89-92. Go to original source...
    25. Formiga F, Nolla JM, Mitjavila F, et al. Bone mineral density and hormonal sta­ tus in men with systemic lupus erythematosus. Lupus 1996;5:623-626. Go to original source...
    26. Formiga F, Moga I, Nolla JM, et al. The association of dehydroepiandrosteron suphate levels with bone mineral density in systemic luopus erythematosus. Clin Exp Rheumatol 1997;15:387-392.
    27. Kipen Y, Buchbinder R, Forber A, et al. Prevalence of reduced bone mineral density in systemic lupus erythematosus and role of steroids. J Rheumatol 1997;24:1922-1929.
    28. Kipen Y, Strauss B, Morand E. Body composition in systemic lupus erythemato­ sus. Brit J Rheumatol 1998;37:514-519. Go to original source...
    29. Kipen Y, Will R, Strauss B, Morand E. Urinary excretion of the pyridinium cross­ links of collagen in systemic lupus erythematosus. Clin Rheumatol 1998;17:271-276. Go to original source...
    30. Hansen M, Halberg P, Kollerup G, et al. Bone metabolism in patiens with syste­ mic lupus erythemasosus. Scand J Rheumatol 1998;27:197-206. Go to original source...
    31. Trapani S, Civinini R, Ermini M, et al. Osteoporosis in juvenile systemic lupus erythematosus: a longitudinal study on the effect of steroids on bone mineral den­ sity. Rheumatol Int I998;I8:45 49.
    32. Li EK,Tam LS, Young RP, et al. Loss ofbone mineral density in Chinese pre-menopausal women with systemic lupus erythematosus treated with corticosteroids. Brit J Rheumatol 1998;37:405^10. Go to original source...
    33. Teichmann J, Lange U, Stracke H, et al. Bone metabolism and bone mineral den­ sity of systemic lupus erythematosus at the time of diagnosis. Rheumatol Int 1999;18:137-140. Go to original source...
    34. Sinigaglia L, Varenna M, Binelli L, et al. Determinants of bone mass in systemic lupus erythematosus: A cross sectional study on premenopausal women. J Rheu­ matol 1999;26:1280-1284.
    35. Kipen Y, Briganti E, Strauss B, et al. Three year followup of bone mineral densi­ ty change in premenopausal women with systemic lupus erythematosus. J Rheu­ matol 1999;26:310-317.
    36. Gilboe I-M, Kvien TK, Haugeberg G, Husby G. Bone mineral density in systemic lupus erythematosus: comparison with rheumatoid arthritis and healthy controls. Ann Rheum Diss 2000;59:110-115. Go to original source...
    37. Jardinet D, Lefebre C, Depresseux G, et al. Longitudinal analysis of bone mineral density in pre-menopausal female systemic lupus erythematosus patients: dele­ terious role of glucocorticoid therapy at the lumbar spine. Rheumatology 2000;39:389-392. Go to original source...
    38. Redlich K, Ziegler S, Kiener HP, et al. Bone mineral density and biochemical pa­ rameters of bone metabolism in female patients with systemic lupus erythemato­ sus. Ann Rheum Diss 2000;59:308-310. Go to original source...
    39. Lakshminarayanan S, Walsh S, Mohanraj M, Rothfield N. Factors associated with low bone mineral density in female patients with systemic lupus erythematosus. J Rheumatol 2001;28:102-108.
    40. Korczowska I, Lacki JK, Leszczynski P, et al. Bone tissue metabolism in systemic lupus erythematosus patients treated with glucocorticosteroids. Pol Arch Med Wewn 2001;106:901-907.
    41. Becker A, Fischer R, Scherbaum WA, Sneider M. Osteoporosis screening in sys­ temic lupus erythematosus: impact of disease duration and organ damage. Lupus 2001;10:809-814. Go to original source...
    42. Becker A, Fischer R, Sneider M. Bone density and 25-OH vitamin D in systemic lupus erythematosus. Z Rheumatol 2001;60:352-358. Go to original source...
    43. Bhattoa HP, Kiss E, Bettembuk P, Balogh A Bone mineral density, biochemical markers of bone turnover, and hormonal status in men with systemic lupus eryt­ hematosus. Rheumatol Int 2001;21:97-102. Go to original source...
    44. Rosa J, Tesař V, Dostál C, et al. Systémový lupus erythematodes jako rizikový fak­ tor osteoporózy. Čes Revmatol 2001;9:59-68.
    45. Bhattoa HP, Bettembuk P, Balogh A, et al. Bone mineral density in women with systemic lupus erythematosus. Clin Rheumatol 2002;21:135-141. Go to original source...
    46. Coimbra IB.Lavras C, Costallat LT. Bone mineral density in systemic lupus eryt­ hematosus and its relation ot age at disease onset, plasmatic estradiol and immunosupresive therapy. Joint Bone Spine 2003;70:40-45. Go to original source...
    47. Uaratanawong S, Deessomchoke U, Lertmahart S, Uaratanawong S. Bone mine­ ral density in premenopausal women with systemic lupus erythematosus. J Rheu­ matol 2003;30:2365-2368.
    48. Vaisberg MW, Kaneno R, Franco MF, Mendes NF: Influnce of cholecalciferol (vitamin D3) on the course of experimental systemic lupus erythematosus in F1 (NZBxW) mice. J Clin Lab Anal 2000;14:91-96. Go to original source...
    49. Cervera R, Khamashta MA, Font J, Sebastiani GD, et al. Morbidity and mortality in systemic lupus erythematosus during a 10-year period: a comparison of early and late manifestations in a cohort of 1,000 patients. Medicine (Baltimore) 2003;82:299-308. inzerát Biomin Go to original source...

    Return to the content


    Clinical Osteology

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.