Clin Osteol 2015; 20(4): 144-149

Serum retinol level and osteoporosis in postmenopausal women with type 2 diabetes mellitusGuidelines

I. Raška Jr., M. Rašková, L. Vojtová, V. Zikán

Background: Patients with type 2 diabetes mellitus (T2DM) are at higher risk of fracture compared with non-T2DM individuals inde­ pendent of bone mineral density (BMD). Biochemical parameters reflecting poor bone quality in vitamin A in the pathogenesis of bone fragility in diabetic population is not fully undestood.

Objective: The objectives of our study were to assess the serum retinol level and to in level and bone or glucose metabolism in T2DM postmenopausal women and control subjects. Design and methods: We conducted a cross-sectional observational study in 57 postmenopausal women with T2DM and 73 postme­ nopausal women without T2DM. Serum retinol levels were measured using high-performance liquid chromatography (HPLC). BMD was d 3.0).

Results: We have found no significant difference in serum retinol level between T2DM postmenopausal women (the mean 0.43 ± 0.2 mg/l) and control subjects (the mean 0.36 ± 0.1 mg/l). T2DM women with osteoporosis had significantly higher serum retinol level than control subjects with osteoporosis (p < 0.05). No association was found betwe duration of diabetes, fasting glucose or glycated hemoglobin in women with T2DM.

Conclusion: In our study serum retinol level is not related to fracture prevalence, BMD or glucose metabolism parameters in T2DM postmenopausal women. However, higher retinol level in T2DM postmenopausal women with osteoporosis admitt a possible contri­ bution of vitamin A to the pathogenesis of bone loss in postmenopausal women wi min A in bone metabolism in T2DM are warranted.

Keywords: Type 2 Diabetes Mellitus, Osteoporosis, Bone Mineral Density, Retinol

Published: December 11, 2015  Show citation

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Raška I, Rašková M, Vojtová L, Zikán V. Serum retinol level and osteoporosis in postmenopausal women with type 2 diabetes mellitus. Osteologický bulletin. 2015;20(4):144-149.
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    References

    1. Sanguineti R, Puddu A, Mach F, Montecucco F, Viviani GL. Advanced glycation end products play adverse Inflamm 2014;2014:975872. Go to original source...
    2. Movahed A, Larijani B, Nabipour I, Kalantarhormozi M, Asadipooya K, Vahdat K, Akbarzadeh S, Farrokhnia M, Assadi M, Amirinejad R, Bargahi A, Sanjdideh Z. Reduced serum osteocalcin concentrations are associated with type 2 diab mellitus and the metabolic syndrome components in postmenopausal women: the crosstalk between bone and energy metabolism. J Bone Miner Metab 2012; 30(6):683-691. Go to original source...
    3. Minambres I, Sánchez-Quesada JL, Vinagre I, Sánchez-Hernández J, Urgell E, de Leiva A, Pérez A. Hypovitaminosis D in type 2 diabetes: relation with featu of the metabolic syndrome and glycemic control. Endocr Res 2014;40(3):160-165. Go to original source...
    4. Muscogiuri G, Nuzzo V, Gatti A, Zuccoli A, Savastano S, Di Somma C, Pivone R, Orio F, Colao A. Hypovitaminosis D: a novel risk factor for coronary heart disease in type 2 diabetes? Endocrine 2015 (Ahead of print). Go to original source...
    5. Starup-Linde J, Vestergaard P. Biochemical bone tu mellitus - A systematic review. Bone 2015,83:149-155. Go to original source...
    6. van Bezooijen RL, Roelen BA, Visser A, van der Wee-Pals L, de Wilt E, Kar M, Hamersma H, Papapoulos SE, ten Dijke P, Lowik CW. Sclerostin is an osteocyte-expressed negative regulator of bon tagonist. J Exp Med 2004;199(6):805-814. Go to original source...
    7. Yamamoto M, Yamauchi M, Sugimoto T. Elevated sclerostin levels are associated with vertebral fractures in patients with type 2 diabetes mellitus. J Clin Endocri Metab 2013;98(10):4030-4037. Go to original source...
    8. Roidt L, White E, Goodman GE, Wahl PW, Omenn GS, Rollins B, Karkeck JM. Association of food frequency questionnaire estimates of vitamin A intake with serum vitamin A levels. Am J Epidemiol 1988;128(3):645-654. Go to original source...
    9. Neuhouser ML, Rock CL, Eldridge AL, Kristal AR, Patterson RE, Cooper DA, Neumark-Sztainer D, Cheskin LJ, Thornquist MD. Serum concentrations of reti­ nol, alpha-tocopherol and the carotenoids are influenced by diet, race and obesity in a sample of healthy adolescents. J Nutr 2001;131(8):2184-2191. Go to original source...
    10. Michaelsson K, Lithell H, Vessby B, Melhus of fracture. N Engl J Med 2003;348(4):287-294. Go to original source...
    11. Harada H, Miki R, Masushige S, Kato S. Gene expression of retinoic acid recep­ tors, retinoid-X receptors, and cellular retinol-binding protein I in bone a gulation by vitamin A Endocrinology 1995;136(12):5329-5335. Go to original source...
    12. Mata-Granados JM, Cuenca-Acevedo JR, Luque de Castro MD, Holick MF, Quesada-Gómez JM. Vitamin D insufficiency together with high serum levels of vitamin A increases the risk for osteoporosis in postmenopausal women. Arch Osteoporos 2013;8:124. Go to original source...
    13. Lind T, Sundqvist A, Hu L, Pejler G, Andersson G, Jacobson A, Melhus H. Vitamin A is a negative regulator of osteoblast mineralization. PLoS One 2013;8(12):e82388. Go to original source...
    14. Broulík PD, Raška I, Brouliková K. Prolonged overdose of all-trans retinoic a enhances bone sensitivity in castrated mice. Nutrition 2013;29(9):1166-1169. Go to original source...
    15. Caire-Juvera G, Ritenbaugh C, Wactawski-Wende J, Snetselaar LG, Chen Z. Vitamin A and retinol intakes and the risk of fractures among participants of the Women's Health Initiative Observational Study. Am J Clin Nutr 2009; 89(1):323-330. Go to original source...
    16. Melhus H, Michaelsson K, Kindmark A, Bergstrom R, Holmberg L, Mallmin H, Wolk A, Ljunghall S. Excessive dietary intake of vitamin A is associated with re­ duced bone mineral density and increased risk for hip fracture. Ann Intern Med 1998;129(10):770-778. Go to original source...
    17. Rejnmark L, Vestergaard P, Charles P, Hermann AP, Brot C, Eiken P, Mosekilde L. No effect of vitamin A intake on bone mineral density and fracture risk in perimenopausal women. Osteoporos Int 2004;15(11):872-880. Go to original source...
    18. Wu AM, Huang CQ, Lin ZK, Tian NF, Ni WF, Wang XY, Xu HZ, Chi YL. The relationship between vitamin A and risk of fracture: meta-analysis of prospective studies. J Bone Miner Res 2014;29(9):2032-2039. Go to original source...
    19. Krempf M, Ranganathan S, Ritz P, Morin M, Charbonnel B. Plasma vitamin A and E in type 1 (insulin-dependent) and type 2 (non-insulin-dependent) adult diabetic patients. Int J Vitam Nutr Res 1991;61(1):38-42. Go to original source...
    20. Tavridou A, Unwin NC, Laker MF, White M, Alberti KG. Serum concentrations of vitamins A and E in impaired glucose tolerance. Clin Chim Acta 1997;266(2): 129-140. Go to original source...
    21. Ylonen K, Alfthan G, Groop L, Saloranta C, Aro A, Virtanen SM. Dietary inta and plasma concentrations of carotenoids and tocopherols in relation to glucose metabolism in subjects at high risk of type 2 diabetes: the Botnia Dietary Stu Am J Clin Nutr 2003;77(6):1434-1441. Go to original source...
    22. Trasino SE, Benoit YD, Gudas LJ. Vitamin A deficiency causes hyperglycemia and loss of pancreatic [3-cell mass. J Biol Chem 2015;290(3):1456-1473. Go to original source...
    23. Gressner AM, Arndt T. Lexikon der Medizinischen Laboratoriumsdiagnostik, Band 1 Klinische Chemie, 1. Auflage Springer Medizin Verlag Heidelberg 2007. Go to original source...
    24. Valdés-Ramos R, Guadarrama-López AL, Martinez-Carrillo BE, BenítezArciniega AD. Vitamins and type 2 diabetes mellitus. Endocr Metab Immune Disord Drug Targets 2015;15(1):54-63. Go to original source...
    25. Brun PJ, Grijalva A, Rausch R, Watson E, Yuen JJ, Das BC, Shudo K, Kagechika H, Leibel RL, Blaner WS. Retinoic acid receptor signaling is required to mai in glucose-stimulated insulin secretion and p-cell mass. FASEB J 2015;29(2): 671-683. Go to original source...
    26. Berry DC, Noy N. All-trans-retinoic acid represses obesity and insulin resistance by activating both peroxisome proliferation-activated re noic acid receptor. Mol Cell Biol 2009;29(12):3286-3296. Go to original source...
    27. Brun PJ, Yang KJ, Lee SA, Yuen JJ, Blaner WS. Retinoids: Potent regulators metabolism. Biofactors 2013;39(2):151-163. Go to original source...
    28. Abahusain MA, Wright J, Dickerson JW, de Vol EB. Retinol, alpha-tocopherol and carotenoids in diabetes. Eur J Clin Nutr 1999;53(8):630-635. Go to original source...
    29. Daousi C, Casson IF, Gill GV, MacFarlane IA, Wilding JPH, Pinkney JH. Prevalence of obesity in type 2 diabetes in secondary care: as diovascular risk factors. Postgrad Med J 2006;82(966):280-284. Go to original source...
    30. Vestergaard P. Discrepancies in bone mineral density and fracture risk in patie with type 1 and type 2 diabetes-a meta-analysis. Osteoporos Int 2007;18(4): 427-444. Go to original source...
    31. Bergmann P, Body JJ, Boonen S, Boutsen Y, Devogelaer JP, Goemaere S, Kaufman J, Reginster JY, Rozenberg SJ. Loading and skeletal development and maintenance. J of Osteoporos 2011;20:786-752. Go to original source...
    32. Napoli N, Faccio R, Shrestha V, Bucchieri S, Rini GB, Armamento-Villareal R. Estrogen metabolism modulates bone density in men. Calcif Tissue Int 2007; 80(4):227-232. Go to original source...
    33. Mata-Granados JM, Luque de Castro MD, Quesada Gomez JM. Inappropriate serum levels of retinol, alpha-tocopherol, 25 hydroxyvitamin D3 and 24,25 dihy­ droxyvitamin D3 levels in healthy Spanish adults: simultaneous assessment by HPLC. Clin Biochem 2008;41(9):676-680. Go to original source...
    34. Kneissel M, Studer A, Cortesi R, Susa M. Retinoid-induced bone thinning is cau­ sed by subperiosteal osteoclast activity in adult rodents. Bone 2005;36(2): 202-214. Go to original source...

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