Mitochondrial DNA, oxidative stress and bone metabolismOriginal contributions

P. Molnárová, V. Palička

Clin Osteol 2015; 20(4): 139-143

Mitochondrial DNA encodes the genes of oxidative phosphorylation for complexes I-IV. Mitochondriae are the place of implemen­ tation of the electron transport chain and therefore are the main producers of reactive oxygen species (ROS), with most of them being formed with participation of complexes I and III (NADH-coenzyme Qoxidoreductase and Q-cytochrome c oxidoreductase). Increased oxidative stress has a negative effect on bone metabolism, bone-forming osteoblasts as well as osteoclasts degrading the bone tissue, and may lead to the development of osteoporosis and other bone diseases. Mitochondrial gene mutations and lowered mitochondrial DNA copy...

Serum retinol level and osteoporosis in postmenopausal women with type 2 diabetes mellitusGuidelines

I. Raška Jr., M. Rašková, L. Vojtová, V. Zikán

Clin Osteol 2015; 20(4): 144-149

Background: Patients with type 2 diabetes mellitus (T2DM) are at higher risk of fracture compared with non-T2DM individuals inde­ pendent of bone mineral density (BMD). Biochemical parameters reflecting poor bone quality in vitamin A in the pathogenesis of bone fragility in diabetic population is not fully undestood. Objective: The objectives of our study were to assess the serum retinol level and to in level and bone or glucose metabolism in T2DM postmenopausal women and control subjects. Design and methods: We conducted a cross-sectional observational study in 57 postmenopausal women with T2DM and 73 postme­ nopausal women without T2DM. Serum retinol...

Diagnosis and treatment of postmenopausal osteoporosis 2015 Statement of the Czech Society for Metabolic Bone DiseasesGuidelines

J. Rosa, F. Šenk, V. Palička, spolupracovali: J. Blahoš, M. Bayer, P. Broulík, P. Horák, P. Kasalický, I. Kučerová, V. Kuba, Š. Kutílek, R. Pikner, V. Vyskočil

Clin Osteol 2015; 20(4): 150-168