Management of ONJ in bone disease and onkology patientsReview articles

J. Jambura, L. Hauer, D. Hrušák, V. Vyskočil, L. Hostička, P. Andrle, P. Pošta, J. Genčur

Clin Osteol 2016; 21(3): 79-88

Medication-related osteonecrosis of the jaw (MRONJ) is a rare but severe complication affecting patients receiving antiresorptive and/or biological therapy influencing bone metabolism. Moreover, the increasing use of these drugs and introduction of high-risk medicines increases the incidence of this condition. The therapy is sometimes very difficult, often lengthy and, so far, without clear consensus among experts. However, recent findings suggest that in the management of osteonecrosis of the jaw, better results are achie­ ved with radical surgical therapy than a conservative approach. Surgical therapy should be indicated as early, regardless of the...

Is obesity really a protective factor for osteoporosis?Short communications

Ľ. Cibičková, J. Schovánek, D. Karásek

Clin Osteol 2016; 21(3): 89-91

Until recently, obesity was consistently regarded as a factor protecting against the development of osteoporosis. However, newer stu­ dies point to associations between abdominal obesity and decreased bone mineral density, increased fractures and the development of osteoporosis. The associations were reported by both population studies and in vitro experiments. Much attention has been given to communication and interaction between bone and visceral adipose tissues. These are mediated by numerous hormone and cytoki­ nes produced by both tissue types and referred to as a bone-fat axis. Additionally, obese patients suffer from problems such as lower physical...

Primary hyperparathyroidism with severe osteoporosis -relapse following five-year complete remissionShort communications

M. Krčma

Clin Osteol 2016; 21(3): 92-95

Primary hyperparathyroidism, a complex disorder of calcium-phosphate metabolism affecting many organs and tissues, is one of less common causes of secondary osteoporosis. Metabolic changes are long-term and the disease is underdiagnosed. The present case re­ port shows some aspects and pitfalls of the diagnosis, treatment and follow-up.

Multidisciplinary approach in the treatment of a comorbid patient with secondary osteoporosis - a clinical case reportInformations

J. Svobodová, R. Fuchsová

Clin Osteol 2016; 21(3): 96-100

News from around the worldLiterature

Clin Osteol 2016; 21(3): 101-104

Report from the Committee meeting of SMOSNews

Clin Osteol 2016; 21(3): 105-106