EditorialEditorial

P. Horák

Clin Osteol 2008; 13(2): 39

Glucocorticoid-induced osteoporosisReview articles

S. Skácelová

Clin Osteol 2008; 13(2): 40-48

Glucocorticoid excess in the organism, either of endogenous (Cushing's syndrome) or exogenous iatrogenic origin, has an adverse im­ pact on both qualitative and quantitative properties of bone tissue, leading to its increased fragility. Glucocorticoid-induced osteopo­ rosis (GIOP) is one of the most common complications of systemic corticotherapy. In glucocorticoid users, the age-and sex-adjusted bone mineral density (BMD) values are lower than expected. Lower BMD correlates with the cumulative dose of corticoids. There is a predilection for the involvement of trabecular bone of the vertebral body. Corticodependent patients have higher risk of fractures...

Clinical manifestations of paraneoplastic syndromes in the musculoskeletal systemReview articles

P. Horák, V. Vavrdová

Clin Osteol 2008; 13(2): 49-56

The authors deal with clinical manifestations of paraneoplastic syndromes affecting the musculoskeletal system. These syndromes may develop in the course of cancer but they may also precede it. According to established criteria by A. Fam, paraneoplastic rheumatic syndromes are classified as follows: articular, muscular, dermal and mixed. These syndromes include hypertrophic osteorthropathy, carcinoma polyarthritis, amyloid arthropathy, dermatomyosistis, paraneoplastic vasculitis, algodystrophic and antiphospholipid syn­ dromes, relapsing polychondritis, oncogenic osteomalacia and polymyalgia rheumatica. Numerous less known entities also have to be...

Relationship between metabolic syndrome and vitamin D and calciumOriginal contributions

K. Brázdilová

Clin Osteol 2008; 13(2): 57-64

Recently, besides other factors that may influence the health status of patients with metabolic syndrome, increasingly more attention has been paid to vitamin D. The results of research conducted in recent years reveal that vitamin D has a proven role in lowering blood pressure, increases the secretion of insulin as well as the sensitivity of peripheral tissues to insulin and, thirdly, leads to some weight loss.

Bone mineral density and selected parameters of bone turnover in patients with systemic lupus erythematosusCase reports

M. Žurek, P. Horák, J. Lukeš, K. Langová, V. Ščudla

Clin Osteol 2008; 13(2): 65-70

Osteomalacia as the first sign of Sjogren's syndromeNews

H. Ciferská, P. Horák, M. Skácelová, A. Smržová, J. Zadražil

Clin Osteol 2008; 13(2): 71-75

At the department of rheumatology, a 44-year-old female was examined with a long history of musculoskeletal pain and significant loss of bone mineral density. The laboratory findings showed higher levels of the bone fraction of alkaline phosphatase and normal calci­ um levels. Bone histomorphometry revealed the presence of osteomalacia. Subsequently, the patient was found to have renal tubular acidosis, increased renal bicarbonate loss, glycosuria and aminoaciduria. Some time later, the diagnosis of primary Sjogren's syndro­ me (SS) was made, with fully manifested clinical and immunological findings. Secondary osteomalacia diagnosed in the patient...

News from around the worldLiterature

Clin Osteol 2008; 13(2): 76-79