Clin Osteol 2004; 9(1): 4-5

Body weight and boneArticles

J. Blahos

The relationship between obesity and bone tissue is being studied concerning the influence of the amount of fat tissue and its changes on bone mine­ ral density (BMD), on markers ofbone turnover and on the risk of osteoporotic fractures. The relationship between body weight and bone mass is most decisively influenced by mechanic and humoral factors. The body weight has a mechanical effect on osteocyte mechanosensors. Other involved im­ portant factors are: embryonal relationship between osteoblasts and adipocytes, the genetic relationship between fat and bone tissue, the influence on vascularisation and the cytokine network. The humoral factors include gastrointestinal hormones (insulin) and adipocyte hormones (estrogens, leptin). The practical impact of the relationship between body weight and bone rests in the calculation of Osteoporosis Self - assessment Tool (OST).

Keywords: body weight, bone mineral density, bone markers, fractures.

Published: June 11, 2004  Show citation

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Blahos J. Body weight and bone. Osteologický bulletin. 2004;9(1):4-5.
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