Clin Osteol 2025; 30(3): 153-160

Metastatic versus osteoporotic vertebral fracturesReview articles

Martin Bibza1, Peter Tisovský1, Boris Šteňo2
1 I. ortopedicko-traumatologická klinika LF UK a UNB, Bratislava
2 II. ortopedicko-traumatologická klinika LF UK a UNB, Bratislava

Differentiating metastatic from osteoporotic vertebral fractures is clinically crucial yet challenging. We summarize key clinical and imaging "red flags" (night pain unrelieved by rest, progression, neurological deficit) and advocate a multimodal diagnostic pathway (MRI, CT; selective PET/CT use). A case initially managed as an osteoporotic fracture illustrates pitfalls of first-line interpretation and the value of image re-evaluation and comprehensive physical examination. Correct recognition of metastatic involvement enabled appropriate staging and subsequent management planning.

Keywords: differential diagnosis, metastases, osteoporosis, spine, vertebral fractures.

Published: September 1, 2025  Show citation

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Bibza M, Tisovský P, Šteňo B. Metastatic versus osteoporotic vertebral fractures. Clinical Osteology. 2025;30(3):153-160.
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