Clin Osteol 2018; 23(4): 146-161

Osteoporosis and fractures in multiple sclerosis: pathogenesis, risk factors, treatment options, and preventionReview articles

Zikán Vít1, Kvasničková Ivana1, Týblová Michaela2
1 III. interní klinika 1. LF UK a VFN v Praze
2 Neurologická klinika 1. LF UK a VFN v Praze

Patients with neurological diseases are at higher risk of osteoporosis and fragility fractures compared to age-matched controls. This review summarizes the risk factors and pathophysiologic pathways that play a role in development of osteoporosis and fractures in multiple sclerosis (MS) patients. The research in this area has been active over recent years. Osteoporosis related fractures cause increased morbidity and mortality and add to the burden of having MS. There are currently no guidelines how to best prevent and treat osteoporosis in patients with neurological diseases. The work proposes an algorithm for the screening, prevention and treatment of osteoporosis in patients with MS.

Keywords: Pathogenesis; Multiple sclerosis; osteoporosis; type 2 diabetes mellitus

Received: November 2, 2018; Accepted: November 22, 2018; Published: December 11, 2018  Show citation

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Zikán V, Kvasničková I, Týblová M. Osteoporosis and fractures in multiple sclerosis: pathogenesis, risk factors, treatment options, and prevention. Clinical Osteology. 2018;23(4):146-161.
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