18-mesačná liečba teriparatidom zlepšuje u pacientov s glukokortikoidmi indukovanou osteoporózou hodnoty hustoty kostného minerálu a trabekulárne kostné skóre: výsledky prospektívneho sledovania (register OSTEO.sk)Original contributions

Payer Juraj, Tomková Soňa, Killinger Zdenko, Brázdilová Kristina, Jackuliak Peter, Vaňuga Peter, Letkovská Alexandra, Masaryk Pavol, Kmečová Zlata, Kužma Martin

Clin Osteol 2018; 23(4): 138-145

Osteoporosis and fractures in multiple sclerosis: pathogenesis, risk factors, treatment options, and preventionReview articles

Zikán Vít, Kvasničková Ivana, Týblová Michaela

Clin Osteol 2018; 23(4): 146-161

Patients with neurological diseases are at higher risk of osteoporosis and fragility fractures compared to age-matched controls. This review summarizes the risk factors and pathophysiologic pathways that play a role in development of osteoporosis and fractures in multiple sclerosis (MS) patients. The research in this area has been active over recent years. Osteoporosis related fractures cause increased morbidity and mortality and add to the burden of having MS. There are currently no guidelines how to best prevent and treat osteoporosis in patients with neurological diseases. The work proposes an algorithm for the screening, prevention and treatment...

Incidence of hip fractures in Slovakia in 2000-2016Review articles

MUDr. Masaryk Pavol, CSc.

Clin Osteol 2018; 23(4): 162-168

Hip fractures are the most serious complication of osteoporosis and therefore a suitable parameter of diagnostics and therapy effectiveness. The aim of this study was to analyze the secular trends of incidence of these fractures in Slovakia during years 2000-2016. According to data from NCZI (National Centrum for Health Informatics) about hospitalization incidence in all Slovak hospitals in persons over 50 years the number of femur fracture (dg. S72) increased from 6029 in year 2000 to 7415 in year 2016, i.e. more than 23 %, which is about 1.5 % per year, in women this increase was 24.2 % and in men 20.4 %. The number of hip fractures, which could...

The role of vitamin D in the treatment of secondary osteoporosis in cancer patientsReview articles

Špániková Beata, Špánik Stanislav

Clin Osteol 2018; 23(4): 169-175

D vitamin plays an important role in the metabolism of calcium and bone metabolism. In addition, it appears that those with lower vitamin D levels have higher incidence of cancer, especially breast, prostate, and colon carcinoma. Breast cancer is the most common malignant disease in women. For postmenopausal patients with positive hormone receptors, hormonal therapy with aromatase inhibitors is often used at various stages. This improves the prognosis of patients, their survival, and reduces the occurrence of distant metastases, but also has side effects in particular on musculoskeletal system. In addition to secondary osteoporosis, arthralgia and...

Clinical perspective of RANK/RANKL/OPG system components in rheumatoid arthritisReview articles

Gažová Andrea, Kužma Martin, Killinger Zdenko, Payer Juraj, Kyselovič Ján

Clin Osteol 2018; 23(4): 176-180

Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory autoimmune disease affecting mainly synovial tissue as its primary target. Uncontrolled disease activity causes not only joint destruction but is associated with increased mortality mainly due to cardiovascular involvement. Understanding the role of cytokines in patophysiology of RA and their link to cardiovascular system could contribute to cardiovascular risk markers detection in RA patients.

An interdisciplinary approach to a patient with acute lymphoblastic leukemiaCase reports

Janečková Paulína; Liščak Boris; Kokavec Milan

Clin Osteol 2018; 23(4): 181-184

The review aimed to present multidisciplinary approach to the patients with acute lymphoblastic leukemia. The case report demonstrate the diversity of clinical and radiographic manifestations of the disease and the need of cooperation between different specialists by treatment. Early recognition of skeletal abnormalities is essential to prevent long-term skeletal sequelae and diminished quality of life observed in patients with leukemia.