Clin Osteol 2016; 21(4): 119-123

Osteoporosis in patients with advanced kidney disease -what is the diagnosis and treatment?Review articles

L. Brunerová

Increasing attention is being paid to bone disease in patients with advanced chronic kidney disease. Low bone mineral density was identified as an independent risk factor for fragility fractures which occur earlier and more frequently in this population than in people with normal renal function. Current trends in the diagnosis and treatment of osteoporosis in patients with severe chronic kidney disease are discussed.

Keywords: osteoporosis, densitometry, chronic kidney disease, chronic kidney disease, mineral and bone di­ sorder, dialysis

Published: December 11, 2016  Show citation

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Brunerová L. Osteoporosis in patients with advanced kidney disease -what is the diagnosis and treatment? Osteologický bulletin. 2016;21(4):119-123.
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    References

    1. Coresh J, Astor B, Greene T, Eknoyan G, Levey A. Prevalence of chronic kidney disease and decreased kidney function in the adult U.S. population: Th Health and Nutrition Examination Survey. Am J Kidney Dis 2013;41:1-12. Go to original source...
    2. National Kidney Foundation. K/DOQI clinical practice guidelines for chronic k ney disease: evaluation, classification, and stratification. Kidney Disease Out­ comes Quality Initiative. Am J Kidney Dis 2002;2:S1-S266.
    3. Hruska KA, Seifert M, Sugatani T. Pthophysiology of the chronic kidney disea­ se-mineral bone disorder. Curr Opin Nephrol Hypertens 2015;24(4):303-309. Go to original source...
    4. Kraut JA, Madias NE. Metabolic Acidosis of CKD: An Update. Am J Kidney Dis 2016;67(2):307-317. Go to original source...
    5. Malluche HH, Ritz E, Lange HP, Kutschera L, Hodgson M, Seiffert U, Schoeppe W. Bone histology in incipient and advanced renal failure. Kidney Int 1976;9:355-362. Go to original source...
    6. Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group. KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). Kidney Int Suppl 2009;(113):S1-130.
    7. Dusilová Sulková S et al. Renální osteopatie. Maxdorf 2007; str. 21-23.
    8. Jamal SA, West SL, Miller PD. Bone and kidney disease: diagnostic and thera­ peutic implications. Curr Rheumatol Rep 2012;14:217-223. Go to original source...
    9. Miller PD. Chronic kidney disease and osteoporosis: evaluation and managem Bonekey Rep 2014;3:542. Go to original source...
    10. Hughes SA, Mendelssohn JG, Tobe SW, McFarlane FA, Mendelssohn DC. Factors associated with suboptimal initiation of dialysis despote early nephrologis ral. Nephrol Dial Transplant 2013;28:392-297. Go to original source...
    11. Dempster DW, Compston JE, Dreznar MK, Glorieux FH, Kanis JA, Malluche H et al. Standarized nomenclature, symbols, and units for bone histomorphone update of the report of the ASBMR histomorphometry nomenclature committee. J Bone Miner Res 2013;28:2-17. Go to original source...
    12. Miller PD. Osteoporosis in Patients with Chronic Kidney Disease: Evaluation and Management In: Basow DS (ed). Up-to-Date. Waltham, MA, USA, 2013.
    13. Yenchek RH, Ix JH, Shlipak MG, Bauer DC, Rianon NJ, Kritchevsky SB, TB, Newman AB, Cauley JA, Fried LF. Health, Aging, and Body Composition Study. Bone mineral density and fract J Am Soc Nephrol 2012;7(7):1130-1136. Go to original source...
    14. Iimori S, Mori Y, Akita W, Kuyama T, Takada S, Asai T, Kuwahara M, Sas Tsukamoto Y. Diagnostic usefulness of bone mineral density and biochemical markers of bone turnover in predicting fracture in CKD stage 5D pati gle-center cohort study. Nephrol Dial Transplant 2012;27(1):345-351. Go to original source...
    15. Ketteler M, Elder GJ, Evenepoel P, Ix JH, Jamal SA, Lafage-Proust MH, Shrof Thadhani RI, Tonelli MA, Kasiske BL, Wheeler DC, Leonard MB. Revisiting KDIGO clinical practice guideline on chronic kidney disease-mineral and bone disorder: a commentary from a Kidney Disease: Improving Global Outcomes con­ troversies conference. Kidney Int 2015;87(3):502-528. Go to original source...
    16. Malluche HH, Davenport DL, Cantor T, Monier-Faugere MC. Bone mineral den­ sity and serum biochemical predictors of bone loss in patients with CKD on dia­ lysis. Clin J Am Soc Nephrol 2014;9(7):1254-1262. Go to original source...
    17. Valkovský I, Tvrdík J, Martínek A, Olšanská R, Dědochová J, Petejová N, Svager Pernicová M, Cermáková Z. Bone mineral density in patients with chronic renal failure at the start of haemodialysis therapy. Vnitr Lek 2012;58(11): 817-824.
    18. Khan MI, Syed GM, Khan AI, Sirwal IA, Anwar SK, Al-Oufi AR, Balbaid KA. Mean bone mineral density and frequency of occurrence of osteopenia and osteo­ porosis in patients on hemodialysis: a single-center study. Saudi J Kidney Dis Transpl 20l4;25(l):38 43.
    19. Brunerová L, Ronová P, Verešová J, Beranová P, Potočková J, Kasalický P, Rychlík I. Osteoporosis and Impaired Trabecular Bone Score in Hemodialysis Ptients. Kidney Blood Press Res 2016;41(3):345-354. Go to original source...
    20. Blomquist GA, Davenport DL, Mawad HW, Monier-Faugere MC, Malluche HH. Diagnosis of low bone mass in CKD-5D patients. Clin Nephrol 2016;85(2):77-83. Go to original source...
    21. Ihlička V, Dusilová-Sulková S, Holečková M, Šafránek R, Pavlíková L. Bone turnover markers and different dialysis procedures. J Bone Miner Res 2014; 28/S-1:S478.
    22. Sprague SM, Bellorin-Font E, Jorgetti V, Carvalho AB, Malluche HH, Ferreira A, D'Haese PC, Drueke TB, Du H, Manley T, Rojas E, Moe SM. Diagnostic Accuracy of Bone Turnover Markers and Bone Histology in Patients With CKD Treated by Dialysis. Am J Kidney Dis 2016;67(4):559-566. Go to original source...
    23. Žamboch K, Krejčí K, Škarda J, Tichý M, Uberall I, Skýpalová P, Langová K, Stejskal D, Švesták M, Zahálková J, Ščudla V, Zadražil J. Histomorphometric dia­ gnostics of renal osteopathy in chronic dialysis patients at high risk of cardio cular disease. Int Urol Nephrol 2015;47(7):1195-1201. Go to original source...
    24. Cejka D, Patsch JM, Weber M, Diarra D, Riegersperger M, Kikic Z, Krestan C, Schueller-Weidekamm C, Kainberger F, Haas M. Bone microarchitecture in hemodia­ lysis patients assessed by HR-pQCT. Clin J Am Soc Nephrol 2011;6(9): 2264-2271. Go to original source...
    25. Negri AL, Del Valle EE, Zanchetta MB, Nobaru M, Silveira F, Puddu M, Barone R, Bogado CE, Zanchetta JR. Evaluation of bone microarchitecture by high-resolution peripheral quantitative computed tomography (HR-pQCT) in he­ modialysis patients. Osteoporos Int 2012;23(10):2543-2550. Go to original source...
    26. Carvalho AB, Carneiro R, Leme GM, Rochitte CE, Santos RD, Miname MH, Moyses RM, Jorgetti V, Canziani ME. Vertebral bone density by quantitative com­ puted tomography mirrors bone structure histomorphometric parameters in hemo­ dialysis patients. J Bone Miner Metab 2013;31(5):551-555. Go to original source...
    27. Silva BC, Leslie WD, Resch H, Lamy O, Lesnyak O, Binkley N, McCloskey EV, Kanis JA, Bilezikian JP. Trabecular bone score: a noninvasive analytical method based upon the DXA image. J Bone Miner Res 2014;29(3):518-530. Go to original source...
    28. McCloskey EV, Odén A, Harvey NC, Leslie WD, Hans D, Johansson H, Barkmann R, Boutroy S, Brown J, Chapurlat R, Elders PJ, Fujita Y, Gluer CC, Goltzman D, Iki M, Karlsson M, Kindmark A, Kotowicz M, Kurumatani N, Kwok T, Lamy O, Leung J, Lippuner K, Ljunggren O, Lorentzon M, Mellstrom D, Merlijn T, Oei L, Ohlsson C, Pasco JA, Rivadeneira F, Rosengren B, SornayRendu E, Szulc P, Tamaki J, Kanis JA A meta-analysis of trabecular bone score in fracture risk prediction and its relationship to FRAX. J Bone Miner Res 2015; doi: 10.1002/jbmr.2734. Go to original source...
    29. Ulivieri FM, Silva BC, Sardanelli F, Hans D, Bilezikian JP, Caudarella R. Util of the trabecular bone score (TBS) in secondary osteoporosis. Endocrine 2014; 47(2):435-448. Go to original source...
    30. Pblletier S, Vilayphiou N, Boutroy S, Bacchetta J, Sornay-Rendu E, Szulc P, Arkouche W, Guebre-Egziabher F, Fouque D, Chapurlat R. Bone microarchitec­ ture is more severely affected in patients on hemodialysis than in those receiving peritoneal dialysis. Kidney Int 2012;82(5):581-588. Go to original source...
    31. Nybo M, Jespersen B, Aarup M, Ejersted C, Hermann AP, Brixen K. Determinants of bone mineral density in patients on haemodialysis or peritoneal dialysis - a cro sectional, longitudinal study. Biochem Med (Zagreb) 2013;23(3): 342-350. Go to original source...
    32. Alem AM, Sherrard DJ, Gillen DL, Weiss NS, Beresford SA, Heckbert SR, Wong C, Stehman-Breen C. Increased risk of hip fracture among patients with end-stage renal disease. Kidney Int 2000;58:396-399. Go to original source...
    33. Maravic M, Ostertag A, Torres PU, Cohen-Solal M. Incidence and risk factors for hip fractures in dialysis patients. Osteoporos Int 2014;25:159-165. Go to original source...
    34. Wakasugi M, Kazama JJ, Taniguchi M, Wada A, Iseki K, Tsubakihara Y, Narita I. Increased risk of hip fracture among Japanese hemodialysis patients. J Bone Miner Metab 2013;31:315-321. Go to original source...
    35. Coco M, Rush H. Increased incidence of hip fractures in dialysis patients with serum parathyroid hormone. Am J Kidney Dis 2000;36:1115-1121. Go to original source...
    36. Coen G, Mantella D, Manni M, Balducci A, Nofroni I, Sardella D et al. 25-hydroxyvitamin D levels and bone histomorphometry in hemodialysis renal osteodys­ trophy. Kidney Int 2005;68:1840-1848. Go to original source...
    37. Ambrus C, Almasi C, Berta K, Deak G, Marton A, Molnar MZ et al. Vitamin D insufficiency and bone fractures in patients on maintenance hemodialysis. Int Urol Nephrol 2011;43:475^82. Go to original source...
    38. Kandula P, Dobre M, Schold JD, Schreiber MJ Jr, Mehrotra R, Navaneethan SD. Vitamin D supplementation in chronic kidney disease: a systematic review and meta-analysis of observational studies and randomized controlled trials. Clin J Am Soc Nephrol 2011;6:50-62. Go to original source...
    39. Dusilová-Sulková S, Safránek R, Vávrová J, Horáček J, Pavlíková L, Palička V. Low-dose cholecalciferol supplementation and dual vitamin D therapy in haemo­ dialysis patients. Int Urol Nephrol 2015;47(1):169-176. Go to original source...
    40. Nagatoya K, Nishimoto K, Shibahara N, Takahashi T, Kanehara H, Ueno N, Yasuda H, Okada S, Ueda H, Hirai K, Inoue T. Hokusetsu Renal Osteodystrophy Study Group. Effects of raloxifene on bone metabolism in postmenopausal women on chronic hemodialysis. Clin Exp Nephrol 2014;19(5):939-946. Go to original source...
    41. Eriguchi R, Umakoshi J, Miura S, Sato Y. Raloxifene ameliorates progressive bo­ ne loss in postmenopausal dialysis patients with controlled parathyroid hormone levels. Clin Nephrol 2009;72(6):423^29. Go to original source...
    42. Tanaka M, Itoh K, Matsushita K, Matsushita K, Moriishi M, Kawanishi H, Fukagawa M. Effects of raloxifene on bone mineral metabolism in postmenopau­ sal Japanese women on hemodialysis. Ther Apher Dial 2011;15 Suppl 1:62-66. Go to original source...
    43. Ishani A, Blackwell T, Jamal SA, Cummings SR, Ensrud KE; MORE Investi­ gators. The effect of raloxifene treatment in postmenopausal women with CKD. J Am Soc Nephrol 2008;19(7):1430-1438. Go to original source...
    44. Lee WL, Cheng MH, Tarng DC, Yang WC, Lee FK, Wang PH. The benefits of estrogen or selective estrogen receptor modulator on kidney and its related di­ sease-chronic kidney disease-mineral and bone disorder: osteoporosis. J Chin Med Assoc 2013;76(7):365-371. Go to original source...
    45. Bergner R, Henrich D, Hoffmann M, Schmidt-Gayk H, Lenz T, Upperkamp M. Treatment of reduced bone density with ibandronate in dialysis patients. J Nephrol 2008;21(4):510-516. Go to original source...
    46. Bergner R, Henrich D, Hoffmann M, Lenz T, Bals G, Ullmann M, Uppenkamp M. High bone-binding capacity of ibandronate in hemodialysis patients. Int J Clin Pharmacol Res 2005;25(3):123-131.
    47. Bergner R, Dill K, Boerner D, Uppenkamp M. Elimination of intravenously ad­ ministered ibandronate in patients on haemodialysis: a monocentre open study. Nephrol Dial Transplant 2002;17(7):1281-1285. Go to original source...
    48. Bergner R. Bisphosphonate therapy in renal osteodystrophy - a review. J Nephrol 2013;26(3):450-455. Go to original source...
    49. Chen CL, Chen NC, Hsu CY, Chou KJ, Lee PT, Fang HC, Renn JH. An open-la­ bel, prospective pilot clinical study of denosumab for severe hyperparathyroidism in patients with low bone mass undergoing dialysis. J Clin Endocrinol Metab 2014;99(7):2426-2432. Go to original source...
    50. McCormick BB, Davis J, Burns KD. Severe hypocalcemia following denosumab injection in a hemodialysis patient. Am J Kidney Dis 2012;60(4):626-628. Go to original source...
    51. Block GA, Bone HG, Fang L, Lee E, P^dhi D. A single-dose study of denosumab in patients with various degrees of renal impairment. J Bone Miner Res 2012; 27(7):1471-1479. Go to original source...
    52. Hiramatsu R, Ubara Y, Sawa N, Hoshino J, Hasegawa E, Kawada M, Imafuku A, Sumida K, Mise K, Hayami N, Suwabe T, Takaichi K. Denosumab for low bone mass in hemodialysis patients: a noncontrolled trial. Am J Kidney Dis 2015; 66(1):175-177. Go to original source...
    53. Giamalis P, Economidou D, Dimitriadis C, Memmos D, Papagianni A, Efstratiadis G. Treatment of adynamic bone disease in a haemodialysis patient with teri­ paratide. Clin Kidney J 2015;8(2):188-190. Go to original source...
    54. Mitsopoulos E, Ginikopoulou E, Economidou D, Zanos S, Pateinakis P, Minasidis E, Memmos D, Thodis E, Vargemezis V, Tsakiris D. Impact of long­ term cinacalcet, ibandronate or teriparatide therapy on bone mineral density ofhe­ modialysis patients: a pilot study. Am J Nephrol 2012;36(3):238-244. Go to original source...

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