Clin Osteol 2014; 19(2-3): 36-41
Bone mineral density in patients with cirrhosis of the liverOriginal contributions
Background: Decreased bone mineral density (BMD) is a common complication of liver cirrhosis.
Objective: This retrospective study of a group of patients with liver cirrhosis aime kers and assessing the relationship between decreased BMD and the studied variables.
Patients and methods: The group comprised 135 patients (88 males and 47 females) with liver cirrhosis. Patients' records were ma nually processed to obtain the studied variables (gender, age, body mass index [BMI], stage of disease, etiology of disease) and inves tigate their relationship with BMD. The DXA scan was used to measure BMD. The relationships between individual variables were assessed by p < 0.05.
Results: Decreased BMD was found in 63.69 % of patients with liver cirrhosis (44.44 % osteopenia, 19.25 % osteoporosis). There were no significant differences with respect to age, severity of disease or gender. There was an association between decreased BMD and BMI. The levels of statistical significance were achieved when the etiology of liver cirrhosis was compared. The most significant de crease in BMD was noted in patients with liver cirrhosis resulting from primary biliary cirrhosis and primary sclerosing cholangitis (76.46 %); the lowest decrease was associated with liver cirrhosis due to nonalcoholic steatohepatitis (38.45 %).
Conclusion: The study found that decreased BMD in liver cirrhosis is influenced by the etiology of cirrhosis, with BMI being a clear ly negative predictor of decreased BMD. Age has no effect on BMD values in patients with liver cirrhosis. Early diagnosis of decrea sed BMD allows timely preventive and therapeutic measures inhibiting the development of severe bone changes often leading to osteoporotic fractures, preventing patients from bein of patients with liver cirrhosis.
Keywords: liver cirrhosis, osteoporosis, densitometry Osteologický bulletin 2014;19(2-3)36-41
Published: December 11, 2014 Show citation
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