Clin Osteol 2004; 9(4): 127-129

Importance of sexual steroids for integrity of the skeletonReview articles

I. Žofková, K. Zajíčková

Importace of sexual steroids for the skeleton exceeds that of other classic calciotropic systems such as parathyroid hormone - 1,25(OH2 vitamin D or somatotropin - IGF-I. Estrogen acts at several levels of bone remodeling and it is a potent predictor of bone mass in women as well as in men. Ex­ traordinary importance of estrogen for integrity of male and female skeleton is probably connected with development of specific nuclear receptors ear­ ly in the evolution, long ago before androgen receptors. Authors observed association between circulating precursors of sex-steroids and some candi­ date genes for bone mass. This association strengthens the hypothesis on common evolution ofboth important interrelating systems - the skeleton and reproduction. In this review the attention is devoted to mechanisms of sex-steroid action and their role in the processes ofbone development and aging.

Keywords: sexual steroids, estrogen, testosterone, dehydroepiandrosterone, androstenedione, bone remodeling, candidate genes for bone me­ tabolism, evolution.

Published: December 11, 2004  Show citation

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Žofková I, Zajíčková K. Importance of sexual steroids for integrity of the skeleton. Osteologický bulletin. 2004;9(4):127-129.
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