Slovo úvodem

prof. MUDr. Vladimír Palička CSc., dr. h. c.

Clin Osteol 2022; 27(4): 115

Circadian rhythms and bone metabolism

Palička Vladimír; Pavlíková Ladislava; Hyšpler Radomír

Clin Osteol 2022; 27(4): 119-125

Circadian rhythms are extremely important regulators of the whole life. The main regulators are external (so called zeitgebers) deeply influenced by the changes in light and dark cycles. Internal regulators, represented by hormonal activities and gene expressions are part of bone metabolism too. Diurnal activities of bone resorption are easily documented by cyclic changes of CTx levels. Rhythmicity is regulated by food and fasting, sleep and its change by night shifts and physical activity. Chronotherapy is important in short-acting drugs, mostly.

Chondrogenic potential of intramembranous skeletal bones

Korenkov Oleksii; Larina Kateryna

Clin Osteol 2022; 27(4): 126-130

Does hormone replacement therapy have a place in the prevention of osteoporosis?

Fait Tomáš

Clin Osteol 2022; 27(4): 131-134

Hormone therapy remains the most effective treatment for vasomotor symptoms and the genitourinary syndrome of menopause and has been shown to prevent bone loss and fracture. In case of the early start of it benefits overweight risks. We do individual tailoring of therapy by doses, components, application way and total period of use.

Osteoporosis in young adults

Zikán Vít

Clin Osteol 2022; 27(4): 135-146

Low-trauma fractures in young adults are most often the result of secondary osteoporosis. Less frequently, the cause of fractures or low bone mineral density (BMD) is a monogenic disease with delayed manifestation in adulthood (e.g. osteogenesis imperfecta) or idiopathic osteoporosis. Low BMD alone may reflect a physiologically low peak bone mass in otherwise healthy individuals and does not mean an increased risk of fractures. For clinical practice, it is important to rule out the secondary causes of osteoporosis and other metabolic or cancer induced bone diseases. Treatment should be causal. Anti-osteoporotic treatment is indicated if causal measures...

Use of PRP for treatment of tibia fracture with delayed consolidation: case report

Maslennikov Serhii; Kozhemyaka Maxim

Clin Osteol 2022; 27(4): 147-150

Výber z najnovších vedeckých informácií v osteológii

Šteňová Emoke

Clin Osteol 2022; 27(4): 151-153