Mnohostranné dopady pandemie

Palička Vladimír

Clin Osteol 2020; 25(4): 173

Může být FRAX přínosnější? Editorial

Palička Vladimír

Clin Osteol 2020; 25(4): 175

Bone and immune system -⁠ osteoimmunology

Šterzl Ivan, Pikner Richard

Clin Osteol 2020; 25(4): 201-205

Bone is a multifunctional organ that responds to various exogenous and endogenous stimuli, such as calcium intake, mechanical stress, aging, tumors, infectious and autoimmune diseases. The basic functions of bone are mechanical, hematopoetic and the regulation of calcium-phosphate metabolism, and both endocrine and immune systems are interacting with them. In the 1990s, the field of osteoimmunology was established, that because of joint interest in estrogens, vitamin D, parathyroid hormone and interactions with the immune system, significantly cooperates with immunoendocrinology. Mechanisms of both adaptive (cells and antibodies) and innate immunity...

Vitamin D and bone quality

Kužma Martin; Kršáková Eva; Kužmová Zuzana; Smaha Juraj; Jackuliak Peter; Killinger Zdenko; Payer Juraj

Clin Osteol 2020; 25(4): 207-211

Introduction: The contribution of vitamin D to the reduction of fractures can be attributed, at least in part, to a beneficial effect on BMD, but also to an effect on bone microstructure. There is little evidence to explain the effect of vitamin D on bone microarchitecture. Objective: To assess the relationship between 25(OH)D3 levels and quantitative / qualitative bone parameters in postmenopausal women. Methods: A cross-sectional analysis of the effect of vitamin D levels on bone quality in postmenopausal women from endocrinology clinics undergoing DXA examination during 10/2015 to 03/2017, measured by BMD and TBS, was performed. Levels of 25 (OH)...

Adjusting conventional FRAX estimates of fracture probability according to the recency of sentinel fractures

Lorentzon A. Kanis H. Johansson N. C. Harvey V. Gudnason G. Sigurdsson K. Siggeirsdottir M. J.

Clin Osteol 2020; 25(4): 177-188

Diagnosis and treatment of Paget´s disease of bone: update 2020

Zikán Vít

Clin Osteol 2020; 25(4): 189-200

Paget's disease of bone is a progressive focal disorder of bone metabolism characterized by an accelerated rate of bone remodeling, resulting in overgrowth of bone at selected sites and impaired integrity of affected bone. The risk of developing Paget's disease increases with age and its onset is typically after age 55. Both genetic and environmental causes are thought to contribute to its pathogenesis. The main clinical manifestations are pain, deformities and secondary consequences of bone overgrowth in affected areas, such as osteoarthritis or nerve impingement, although many patients are asymptomatic. Radionuclide bone scan, in addition to targeted...

Nutritional (vitamin D deficient) rickets -⁠ a neglected diagnosis? Case report

Kutílek Štěpán, Rondziková Eva, Pečenková Kamila, Vracovská Martina, Pikner Richard, Švábková Marie Radová Eva, Benešová Šperlová Alžběta, Šteinerová Martina, Hubatová Šárka

Clin Osteol 2020; 25(4): 213-218

Nutritional (vitamin D deficient) rickets is currently considered a rare disease, due to overall vitamin D prophylaxis throughout the infantile period. However, nutritional rickets has to considered in children from families of low socio-economic status and in infants of uncooperative parents. We present a case of a two year old girl, from a family of very low socio-economic status, where uncooperative parents completely neglected vitamin D prophylaxis in the first year of life and the patient was referred because of psychomotor retardation and late onset of (waddling) gait. Biochemical assessment revealed high values of serum alkaline phosphatase...