Comparison of the effect of teriparatide and risedronate on bone loss in postmenopausal women with multiple sclerosis treated with low-dose glucocorticoidsReview articles

D. Michalská, V. Zikán, M. Týblová, M. Rašková, E. Havrdová, I. Raška Jr.

Clin Osteol 2015; 20(1): 3-9

The aim of the study was to compare changes in bone mineral density (BMD) and bone turnover markers (BTM) in postmenopausal women with multiple sclerosis (MS) treated with teriparatide (TPTD) or risedronate. The study involved 71 MS women treated with low-dose glucocorticoids (GC). Motor function was evaluated using the Kurtzke Expanded Disability Status Scale (EDSS). At 12 months, the BMD of the lumbar spine significantly increased from baseline in both treatment groups (p < 0.001) without significant differences between them (+7.4 ± 8 % and +2.8 ± 2.9 % for TPTD and risedronate, respectively, p = 0.09). There were no significant...

Depression and osteoporosisReview articles

L. Brunerová

Clin Osteol 2015; 20(1): 10-14

The relationship between depression and osteoporosis is reciprocal. Depressed patients show lower bone mineral density and a higher fracture risk due to their "unhealthy" lifestyle, higher risk of falls, use of antidepressant medication and hormonal and mediator chan­ ges (particularly of the serotonergic system). Among antidepressants, selective serotonin reuptake inhibitors (SSRIs) are thought to be associated with the highest risk for osteoporosis. The risk of fracture steeply increases after treatment initiation due to vegetative disturbances; after adjustment of the autonomic nervous system, the risk slightly increases with the length of the treatment...

Paget's disease of bone?Review articles

M. Skácelová, P. Horák, E. Dokoupilová, E. Kačerová, J. Škarda

Clin Osteol 2015; 20(1): 15-20

After osteoporosis, Paget's disease is the second most common type of metabolic skeletal disorders. It is primarily characterized by im­ paired osteoclast function. It is a localized disease of bone remodeling (occurring only in certain skeletal regions, unlike systemic me­ tabolic bone diseases). The etiology is unknown. Chaotic bone remodeling occurs, with formation of poor quality bone of cotton wool appearance. The disease is mostly asymptomatic, with patients being examined for elevated serum levels of alkaline phosphatase. The clinical manifestations are dominated by pain at the site of bone involvement and development of deformities. The complications...

Bone metabolism disorders in liver and gastrointestinal diseasesReview articles

T. Koller, J. Kollerová, J. Payer

Clin Osteol 2015; 20(1): 21-28

Normal functioning of the digestive tract and the liver is important for normal bone metabolism. Patients with chronic cholestasis in primary biliary cirrhosis or primary sclerosing cholangitis and those with cirrhosis are most commonly affected by metabolic bone disease. Among gastrointestinal diseases, disorders of bone metabolism are found in celiac disease, ulcerative colitis, Crohn's disease, chronic pancreatitis, and in conditions following gastrectomy. Knowledge and anticipation of disorders of bone metabolism allow ear­ ly initiation of preventive measures and early diagnosis of severe bone metabolism disorders. Patients who are candidates...

News from around the worldLiterature

Clin Osteol 2015; 20(1): 29-32

Professional adviceNews

Clin Osteol 2015; 20(1): 33-34

Report from the Committee meeting of SMOSNews

Clin Osteol 2015; 20(1): 35