Surprisingly low bone density in obese patients undergoing bariatric surgeryOriginal contributions

M. Bužga, V. Šmajstrla, L. Bortlík, Z. Švagera, I. Závacká, P. Holéczy

Clin Osteol 2012; 17(2): 43-49

Aim: Low body mass index (BMI) is the major risk factor for osteoporosis. Obesity, on the contrary, is considered to be a protective factor for the skeleton. However, some studies have shown that only moderate overweight and obesity have beneficial effects on the skeleton, while heavy and morbid obesity (BMI over 35, eventually 40 kg/m2) is disadvantageous for the skeleton. The aim of this stu­ dy wa sity. Material and methods: Ninety-two patients were included in a prospective pilot study on the effects of the gastric sleeve resection of BMD and bone metabolism. We investigated these morbidly obese patients (21 men and 71 women) with two-photon bone...

The risk of osteoporosis and fractures in patients with multiple sclerosisOriginal contributions

V.Zikán

Clin Osteol 2012; 17(2): 50-58

Both women and men with multiple sclerosis (MS) are at increased risk of developing osteoporosis and fractures. The principal factor resulting in low bone mass and increased fracture risk in MS is immobility. The vitamin D deficiency, treatment with glucocortico­ ids and / or antidepressants and probably also own disease MS may contribute to development of osteoporosis. Osteoporosis-related fractures cause increased morbidity and mortality and add to the burden of having MS. Therefore, bone health assessment including bone mineral density measurement should be a part of the integral management of persons with MS. There are currently no guideli­ nes...

Body composition as a factor influencing bone density in postmenopausal womenOriginal contributions

A. Gába, O. Kapuš

Clin Osteol 2012; 17(2): 59-64

Aim: To analyze bone mineral density composition in postmenopausal women. Methods: Ninety-seven women, aged 50-77 years, participated in this study. BMD and body composition were assessed by dual-ener­ gy x-ray absorptiometry (DXA). In addition to whole-body parameters, BMD of the lumbar spine, proximal femur and rib area was measur trunk. Results: Significant association was observed between whole-body BMD and BFM (r = 0.41; p < 0.05) and LBM (r = 0.39; p < 0.05). BFM (r = 0.24; p < 0.05) of the trunk was a stronger predictor of lumbar BMD than LBM (r = 0.18; p > 0.05). Although the results of the statistical analysis showed a significant...

Serum homocysteine levels in children with fractures and low bone mineral density - a pilot studyOriginal contributions

Š. Kutílek, P. Řeháčková, V. Němec, E. Bočkayová

Clin Osteol 2012; 17(2): 65-68

Background: High serum homocysteine (S-Hcy) levels are associated with low bone mineral density (BMD) and increased fracture risk in postmenopausal women. So far, data on S-Hcy and bone health are lacking in children and adolescents. Patients, Methods: We assessed S-Hcy levels in 19 children and adolescents (12 boys and 7 girls; mean age 14.9 ± 3.3 years) with pre­ valent low-energy trauma fractures (mean 4 ± 2.6 per patient) and/or low spinal L1-L4 BMD (below -2SD Z-score; DXA Lunar GE). Other assessments included serum alkaline phosphatase (S-ALP) and serum CrossLaps. At the time of assessment, the children were not taking any Z-scores...

News from around the worldLiterature

Clin Osteol 2012; 17(2): 69-72