Vitamin D receptor gene BsmI polymorphism and bone phenotypes in the region of Central MoraviaOriginal contributions

P. Hrdý, P. Novosad, P. Fojtík, P. Horák, R. Richterová

Clin Osteol 2012; 17(1): 3-7

In recent years, results of studies in exposed families or association projects have supported the significant role of heredity in the etio­ logy of osteoporosis. In the description of clinical manifestations of osteoporosis, various surrogate bone phenotypes have been used, including bone mineral density of the lumbar spine and femur, hip geometry, microarchitecture, bone turnover markers and skeletal fractures. The relationship between BsmI polymorphism of the vitamin D receptor gene and bone phenotypes has been analyzed to track one of possible link between heredity and clinical manifesta

Vascular calcifications in patients with chronic kidney failure: epidemiology, diagnosis and possible therapyReview articles

F. Švára

Clin Osteol 2012; 17(1): 8-13

Vascular calcifications (VCs) are significantly more frequent in patients with chronic kidney disease than in the normal population. The high incidence of VCs and their progression are among factors causing high morbidity and mortality in these patients. The dia­ gnosis of VCs is most frequently based on radiological and ultrasound examinations. However, the methods used for quantifying the incidence of VCs are rather varied. Medications used to treat CKD-MBD may both decelerate and acceler

Diagnosis, prevention and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD): KDIGO guideline and subsequent initiatives of national and multinational working groupsReview articles

S. Dusilová Sulková

Clin Osteol 2012; 17(1): 14-20

The article states the basic principles of the 2 ney disease-mineral and bone disorder (CKD-MBD). The definition and characteristics of CKD-MBD were first introduced in 2006. It represents a new perspective on renal bone disease, taking into consideration pathophysiological and clini vascular system in chronic kidney disease and failure. The guideline is supported by defined target concentrations of laboratory markers (serum levels of calcium, phosphorus, parathor­ mone and calcidiol) in individual stages of chronic kidney disease (CKD), including dialysis patients (CKD 5D) and transplantation patients (CKD T). It includes evaluation techniques focused...

Modification of the RANK/RANKL/OPG signaling pathwayInformations

O. Růžičková

Clin Osteol 2012; 17(1): 21-31

Secondary prevention of osteoporosis among general practitionersReview articles

Š. Blažková, M. Vytřísalová, J. Štěpán, V. Palička, S. Býma, T. Hála, J. Vlček

Clin Osteol 2012; 17(1): 32-35

Objectives: General practitioners (GPs) should play an integral role in the prevention tive of this study was to evaluate their activities in the secondary prevention of OP. Methods: We analyzed a postal questionnaire survey among a randomly selected sample of GPs practicing in the Czech Republic. Information on demograp barriers were analyzed. Results: The questionnaire return rate was 38 % (n = 525) and the respondents' mean age was 52 years. Fracture as a consequence of OP was considered by 91% of respondents, but by more than half of them only sometimes or exceptionally. Osteoporotic etiology was most often suspected because of the patient's age...

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Clin Osteol 2012; 17(1): 36-39