Mortality of patients with fractures of the proximal end of the femurReview articles

S. Tomková, M. Varga, M. Šašala

Clin Osteol 2009; 14(1): 3-6

Purpose of the study: Mortality rates at different times during the first year following hip fractures. Material and procedure: All patients, both men and women, hospitalized in the departments of general surgery or orthopaedics of our hospital for osteoporotic hip fractures (S72.X in the MKCH 10) between 1995 and 2002. We excluded patients younger than 50 years of age and those who did not meet the criteria for osteoporotic fractures. The study intervals were defined as follows: up to 10 days, 10 days to 3 months and 3 months to 1 year after hip fracture. Cumulative mortality at 3 months and 1 year after hip fracture was also assessed. The data were...

Oestrogen hormone replacement therapy to prevent osteoporosisReview articles

M. Borovský

Clin Osteol 2009; 14(1): 7-10

The use of hormone therapy in the prevention of osteoporosis has beenjustified by data from biology, epidemiology, preclinical as well as observational and randomized clinical studies. Reduction of the clinical impact of oestrogen deficiency by their replacement is sta­ tistically significant, clinically relevant and biologically explained. Low-dose hormone replacement therapy in postmenopausal women minimizes potential side effects and probably increases compliance. Also, low doses of oestrogen may at least reduce potential thera­ py-associated risks while maintaining the positives of conventional hormone therapy. At present, prevention of osteoporosis...

Free flap transfer and its role in the radical treatment of chronic osteomyelitis of the tibiaReview articles

A. Nejedlý, J. Záhorka, V. Džupa

Clin Osteol 2009; 14(1): 11-14

Chronic osteomyelitis is an inflammatory disease of bones and adjacent soft tissues resulting in impaired perfusion. Radical treatment methods include thorough debridement of both the skeleton and soft tissues and covering the resulting defect with a free flap with in­ dependent vascular supply. After transfer, the flap has multiple essential roles. It provides enough perfused tissue of good quality to cover the exposed skeletal bone. The flap contains enough tissue to enable further surgical interventions related to the skeleton. In the early postoperative period, systemically administered antibiotics in adequate concentrations are brought to the...

Ibandronate in the treatment of postmenopausal osteoporosis: one drug, two optionsReview articles

T. Hála

Clin Osteol 2009; 14(1): 15-19

McCune-Albright syndrome - 11 years of experience with bisphosphonate treatmentReview articles

J. Kollerová

Clin Osteol 2009; 14(1): 22-28

A case report of an adult female patient with McCune-Albright syndrome is presented. The clinical picture is dominated by bone in­ volvement, hyperthyroidism and persistent hyperoestrogenism. There is no widely accepted consensus in the treatment of these con­ ditions. Although administration of bisphosphonates is beneficial, no available treatment can completely stop the progression of bone disease. Treatment of hyperoestrogenism is still a matter of debate and is reserved for patients who wish to conceive. The clinical si­ gnificance of other organ system involvement such as sinus tachycardia, long QTc or liver disease is not yet clear. The case...

News from around the worldLiterature

Clin Osteol 2009; 14(1): 29-32

Vysočina Region Osteology Centre, Havlíčkův Brod HospitalNews

F. Šenk

Clin Osteol 2009; 14(1): 33

30th Annual Meeting of the American Society for Bone and Mineral Research. Palais des congres de Montréal, Montréal, Québec, Canada; 12.-16. 9. 2008News

M. Bayer

Clin Osteol 2009; 14(1): 34-35

The 2008 Metabolic Bone Disease Society PrizeNews

Clin Osteol 2009; 14(1): 36