Statins and bone metabolismArticles

R. Ištok, M. Stančíková, K. Švík, J. Rovensky

Clin Osteol 2003; 8(1): 4-5

Reseach revealed that statins, inhibitors of 3-hydroxy-3-methylglutaryl CoA reductase, used in the treatment of hyperlipidaemia, can stimulate bone formation as well as inhibit bone resorption. Their mechanism of action on both osteoblasts and osteoclasts is most probably due to the inhibition of protein prenylation due to a lack of isoprenoid intermediate products of the mevalonate pathway inhibited by statins. So far,the results of clinical tri­ als that investigated the effect of statin administration on bone metabolism are highly contradictory. With systemic administration, only a small pro­ portion of the statins now used in the management of...

Developing guidelines in osteologyArticles

V. Palička

Clin Osteol 2003; 8(1): 6

Recommended guidelines for diagnosis and treatment of postmenopausal osteoporosisArticles

Clin Osteol 2003; 8(1): 8-13

Calcimimetics - perspective agents in the treatment of hyperparathyroidismArticles

Š. Kutílek, M. Bayer

Clin Osteol 2003; 8(1): 14-17

Extracellular calcium ion concentration is the major determinant of parathyroid hormone (PTH) secretion from parathyroid cells. This mechanism is regulated through a 120 kDa calcium sensing receptor (CaSR). In hyperparathyroidism (HPT), excessive PTH is secreted and calcium sensitivity of the cells is reduced due to decreased expression of CaSR. Modulation of the sensitivity of parathyroid cells to calcium is possible through the use of calci­ mimetics. Calcimimetics are small organic molecules that activate CaSR and thus inhibit PTH secretion. Two mechanistically distinct classes of calci­ mimetics have been identified: type I which are full agonists...

Milk and diary products - an importatnt nutritional component both in childern an adultsInformations

J. Dostálová

Clin Osteol 2003; 8(1): 18-22

Congress AnnouncementsInformations

Clin Osteol 2003; 8(1): 23

Pediatrické pracovní skupiny založení při ASBMRInformations

S. Kutílek

Clin Osteol 2003; 8(1): 24

Minutes of the Committee meeting of the Society for metabolic bone diseasesInformations

Clin Osteol 2003; 8(1): 25

Pokyny autorůmInformations

Clin Osteol 2003; 8(1): 27-28