Clin Osteol 2025; 30(2): 114-120

MikroRNA ako potencionálne bioprediktory pre osteoporózuReview articles

Karolína Kubalová, Marta Mydlárová Blaščáková
Department of Biology, Faculty of Humanities and Natural Sciences, University of Presov,Prešov, Slovakia

Osteoporóza je celosvetovo vysoko frekventované ochorenie s vysokou morbiditou a mortalitou v dôsledku zlomenín. Príčinou osteoporózy je prevaha osteoresorpcie nad novotvorbou kostí. Štúdium nových epigenetických faktorov spojených s týmto ochorením môže rozšíriť poznatky o patogenéze a epidemiológii tohto ochorenia. Spomedzi známych epigenetických mechanizmov sú miRNA jedným z najviac študovaných regulátorov génovej expresie. miRNA majú kľúčovú úlohu pri regulácii kostnej homeostázy a metabolizme. Sú prítomné v telesných tekutinách vrátane séra, čo naznačuje, že cirkulujúce miRNA by mohli slúžiť ako jednoduché neinvazívne biomarkery pre diagnostiku osteoporózy. Cieľom tohto prehľadového článku bolo poukázať na biogenézu, detekciu, význam miRNA ako nových biomarkerov asociovaných s osteoporózou.

Keywords: biogenéza, epigenetika, miRNA, osteoporóza.

Published: June 1, 2025  Show citation

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Kubalová K, Mydlárová Blaščáková M. MikroRNA ako potencionálne bioprediktory pre osteoporózu. Clinical Osteology. 2025;30(2):114-120.
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