Clin Osteol 2007; 12(3): 96-99

Biology of calcitoninReview articles

M. Bayer

Calcitonin, the only hypocalcaemic factor in the organism, was discovered in the late 1950s. Soon after, its origin from the thyroid C cells was documented. The direct action of calcitonin on osteoclasts was evidenced in the early 1980s. These discoveries were followed by cloning and sequencing of calcitonin receptors. Specific regions of the receptor necessary for ligand binding and intracellular sig­ nalling through cyclic AMP and calcium have been identified. This review summarizes the current knowledge about the structure, cel­ lular and molecular actions of fish, mammalian and human calcitonin as well as about its related peptides: alpha- and beta-calcitonin gene-related peptides, adrenomedullin, amylin, and

Keywords: calcitonin, history, effects, derivatives Osteologický bulletin 2007, 12 (3)96-100

Published: December 11, 2007  Show citation

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Bayer M. Biology of calcitonin. Osteologický bulletin. 2007;12(3):96-99.
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