Clin Osteol 2007; 12(2): 49-51

The role of vitamin K in bone metabolismReview articles

I. Žofková

Keywords: vitamín K, Glu-osteokalcin, y-karboxylace, Gla-osteokalcin, osteoporóza v SUMMARY

Published: December 11, 2007  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Žofková I. The role of vitamin K in bone metabolism. Osteologický bulletin. 2007;12(2):49-51.
Download citation

References

  1. Leveille SG, LaCroix AZ, Koepsell TD, Beresford S, Van Belle G, Buchner DM. Do dietary antioxidants prevent postmenopausal bone loss? Nutrition Res 1997; 17:1261-1269. Go to original source...
  2. Ganta DR, McCarthy M-B, Gronowicz GA Ascorbic acid alters collagen integrins in bone culture. Endocrinology 1997;138:3606-3612. Go to original source...
  3. Advani S, Wimalawansa SJ. Bones and nutrition: common sense supplementation for osteoporosis. Curr Womens Health Rep. 2003;3:187-192.
  4. Wermeer C, Shearer MJ, Zittermann A, Bolton-Smith C, Szulc P, Hodges S et al. Beyond deficiency: potential benefits of increased intakes of vitamin K for bone and vascular health. Eur J Nutr 2004;43:325-335. Go to original source...
  5. Kaneki M, Hosoi T, Ouchi Y, Orimo H. Pleiotropic actions of vitamin K: protec­ tor of bone health and beyond? Nutrition 2006,22:845-852. Go to original source...
  6. Shearer MJ. The roles of vitamin D and K in bone health and osteoporosis pre­ vention. Proc Nutr Soc 1997;56:915-937. Go to original source...
  7. Proudfoot D, Shanahan CM. Molecular mechanisms mediating vascular calcifica­ tion: role of matrix Gla protein. Nephrology (Carlton) 2006;11455-461. Go to original source...
  8. Hoshi K, Nomura K, Sano Y, Koshihara Y. Nuclear vitamin K-2 binding protein in human osteoblasts - Homologue to glyceraldehyde-3-phosphate dehydrogena­ se. Biochem Pharmacol 1999;58:1631-1638. Go to original source...
  9. Koshihara Y, Hoshi K. Vitamin K2 enhances osteocalcin accumulation in the extra­ cellular matrix of human osteoblasts in vitro. J Bone Miner Res 1997;12:431-43 8. Go to original source...
  10. Kawata T, Zernik JH, Fujita T, Tokimasa C, Tanne K. Mechanism in inhibitory effects of vitamin K-2 on osteoclastic bone resorption: In vivo study in osteopetrotic (Op/op) mice. J Nutr Sci Vitaminol 1999;45:501-507. Go to original source...
  11. Sun JS, Tsuang YH, Huang WC, Chen LT, Hang YS, Lu FJ. Menadione-induced cytotoxicity to rat osteoblasts. Cell Mol Life Sci 1997;53:967-976. Go to original source...
  12. Akiyama Y, Hara K, Kobayashi M, Tomiuga T, Nakamura T. Inhibitory effect of vitamin K-2 (menatetrenone) on bone resorption in ovariectomized rats: A histomorphometric and dual energy X-ray absorptiometric study. Jap J Pharmacol 1999;80:67-74. Go to original source...
  13. Plantalech L, Guillaumont M, Vergnaud P, Leclercq M, Delmas PD. Impairment of gamma carboxylation of circulating osteocalcin (bone gla protein) in elderly women. J Bone Miner Res 1991;6:1211-1216. Go to original source...
  14. Soontrapa S, Soontrapa S, Bunyaratavej N. Serum concentration of undercarboxylated osteocalcin and the risk of osteoporosis in thai elderly women. J Med As­ soc Thai 2005;88:S29-32.
  15. Greer FR. Vitamin K status of lactating mothers and their infants. Acta Paediatr 1999; 88, suppl. 430:95-103. Go to original source...
  16. Vergnaud P, Garnero P, Meunier PJ, Bréart G, Kamihagi K, Delmas PD. Under­ carboxylated osteocalcin measured with a specific immunoassay predicts hip frac­ ture in elderly women: The EPIDOS study. J Clin Endocrinol Metab 1997;82: 719-724. Go to original source...
  17. Sokoll LJ, Booth SL, Davidson KW, Dallal GE, Sadowski JA Diurnal variation in total and undercarboxylated osteocalcin: Influence of increased dietary phylloquinone. Calcif Tissue Int 1998;62:447^52. Go to original source...
  18. Gundberg CM. Vitamin K status and bone health: An analysis of methods for de­ termination of undercarboxylated osteocalcin. J Clin Endocrinol Metab 1998;83: 3258-3266. Go to original source...
  19. Philip WJ, Martin JC, Richardson JM, Reid DM, Webster J, Douglas AS. Decre­ ased axial and peripheral bone density in patients taking long-term warfarin. QJM: Mon J Assoc Physicians 1995;88:635-640.
  20. Kohlmeier M, Saupe J, Shearer MJ, Schaffer K, Asmus G. Bone health of adult hemodialysis patients is related to vitamin K status. Kidney Int 1997;51: 1218-1221. Go to original source...
  21. Liu G, Peacock M. Age- related changes in serum undercarboxylated osteocalcin and its relationships with bone density, bone quality, and hip fracture. Calcif Tis­ sue Int 1998;62:286-289. Go to original source...
  22. Cockayne S, Adamson J, Lanham-New S, Shearer MJ, Gilbody S, Torgerson DJ. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials. Arch Intern Med 2006;166:1256-1261. Go to original source...
  23. Žofková I, Hill M, Palička V. Association between serum undercarboxylated oste­ ocalcin and bone density and/or quality in early postmenopausal women. Nutriti­ on 2003;19:1001-1003. Go to original source...
  24. Knapen MH, Schurgers LJ, Vermeer C. Vitamin K(2) supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteo­ porosis Int 2007; Jul; 18(7):963-972. Go to original source...
  25. Shiraki M, Shiraki Y, Aoki C, Hosoi T, Inoue K, Kaneki M, Ouchi Y. Associati­ on of bone mineral density with apolipoprotein E phenotype. J Bone Miner Res 1997;12:1438-1445. Go to original source...
  26. Kimura R, Kokubo Y, Miyashita K, Otsubo R, Nagatsuka K, Otsuki T et al. Poly­ morphisms in vitamin K-dependent gamma-carboxylation-related genes influence interindividual variability in plasma protein C and protein S activities in the ge­ neral population. Int J Hematol 2006;84:387-389. Go to original source...
  27. Kinoshita H, Nakagawa K, Narusawa K, Goseki-Sone M, Fukushi-Irie M, Mizoi L et al. A functional single nuicleotide polymorphism in the vitamin-K-dependent gamma-glutamyl carboxylase gene (Arg325Gln) is associated with bone mineral density in elderly Japanese women. Bone 2007;40:451-456. Go to original source...
  28. Yatsui T, Miyatani Y, Tomita J, Yamada M, Uemura H, Miura M, Irahara M. Ef­ fect of vitamin K2 treatment on carboxylation of osteocalcin in early postmeno­ pausal women. Gynecol Endocrinol 2006;22:455-459. Go to original source...
  29. Iwamoto I, Kosha S, Noguchi S, Murakami M, Fujino T, Douchi T, Nagata Y. A longitudinal study of the effect of vitamin K-2 on bone mineral density in post­ menopausal women: a comparative study with vitamin D-3 and estrogen-progestin therapy. Maturitas 1999;31:161-164. Go to original source...
  30. Somekawa Y, Chigughi M, Harada M, Ishibashi T. Use of vitamin K-2 (menatet­ renone) and 1,25-dihydroxyvitamin D-3 in the prevention of bone loss induced by leuprolide. J Clin Endocrinol Metab 1999;84:2700-2704. Go to original source...
  31. Sugiyama T, Tanaka H, Kawai S. Vitamin Kplus vitamin D treatment ofbone pro­ blems in a child with skeletal unloading. J Bone Miner Res 1999;14:1466-1467. Go to original source...
  32. Weber P. Vitamin K and bone health. Nutrition 2001;17:880-887. Go to original source...
  33. Tanada I, Oshima H. Vitamin K2 as a potential therapeutic agent for glucocorti­ coid-induced osteoporosis. Clin Calcium 2006;16:1851-1857.
  34. O'Connor E, Molgaard C, Michaelsen KF, Jakobsen J, Lamberg-Allardt CJ, Cash­ man KD. Serum percentage undercarboxylated osteocalcin, a sensitive measure of vitamin K status, and its relationship to bone health indices in Danish girls. Br J Nutr 2007;97:661-666. Go to original source...
  35. Ryan-Harshman M, Aldoori W. Bone health. New role for vitamin K? Can Fam Physician 2004;50:993-997.
  36. Konakion MM Paediatric. Int. Standard Prescibing Information, Jan. 1998; RO 01­ 6722/139:1-5.




Clinical Osteology

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.