Clin Osteol 2003; 8(4): 135-137

The role of leptin in bone metabolism - what do we knowArticles

M. Bayer, ©. Kutilek

Leptin is a 14kDa polypeptide, produced by fat cells. Leptin plays a role in signalisation of satiety and inhibition of adipocytes differentiation by nega­ tive feedback. There exists a rich discussion on possible role of leptin in bone metabolism in literature. Leptin is able to induce bone tissue accumula­ tion due to its angiogenic and osteogenic influence on bone cells precursors during fetal period. Leptin reduces bone turnover rate by increasing osteoprotegerin levels in human marrow stromal cells as well as mononuclear cells in mature bone tissue. Leptin directly induces the secretion of interleukin-1 receptor antagonist in human monocytes. Peripheral administration of leptin results in enhanced cortical bone formation while intra­ cerebral administration to laboratory animals results in decreasing bone formation through hypothalamic receptors activation. Final effect depends on numerous factors including actual blood-brain barrier status. In study with nearly six thousand participants, serum leptin concentration did not ap­ pear to affect directly bone mineral de

Keywords: leptin, bone metabolism.

Published: December 11, 2003  Show citation

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Bayer M, Kutilek ©. The role of leptin in bone metabolism - what do we know. Osteologický bulletin. 2003;8(4):135-137.
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