Clin Osteol 2003; 8(4): 125-130

The evaluation of bone mineral density and risk factors of osteoporosis in patients with diffuse connective tissue diseasesArticles

M. Žurek, P. Horák, Z. Pospíšil, T. Kraina, L. Kusá, V. Ščudla

This study evaluates the bone mineral density and other risk factors of osteoporosis in the group of 105 patients with autoimmune systemic diseases, 55 females with systemic lupus erythematosus (37 pre-, and 18 postmenopausal), 20 females with systemic sclerosis, 10 patients with dermatomyositis or polymyositis, 20 women with rheumatoid arthritis and in the group of healthy controls. Bone mineral density was measured by the Lunar Prodigy in the area L2-L4, proximal femur, and distal forearm. In the area L2-L4 the osteoporosis was present in 10 %, osteopenia in 30 %, in the hip region os­ teoporosis was found in 5 %, osteopenia in 34 %. In the region of distal forearm the osteoporosis was present in 9 %, osteopenia in 37 %, in the region of ultra distal forearm the incidence of osteoporosis was highest, was found in 16 %, osteopenia in 45 % of patients. There was an inverse correlation bet­ ween the age of onset of disease and BMD index in the forearm region, in other region no significant relation was present. BMD of L2-L4, femoral ne­ ck and forearm had inverse correlation with the time before DXA measurement. In all region except neck of femur there was found a significant in­ verse correlation with age ofpatients. BMD in L region, femur and total forearm score correlated with weight ofpatients. In the group of premenopausal women with SLE the osteoporosis or osteopenia were found especially in those females with earlier onset of disease (average 14.6 and 22.6 years, res­ pectively). On the other side in females with later onset of disease (29.9 years) the trend toward higher values of BMD was observed. In the group of postmenopausal women with SLE the incidence of osteoporosis or osteopenia was higher (L2- L4 17 % respectively 33 %, neck of femur 6 % respective­ ly 47 %). Osteoporosis is an important complication of autoimmune systemic diseases and rheumatoid arthritis; its etiology is multifactorial with signi­ ficant influence of glucocorticoid-induced osteoporosis and deserves the diagnostic and therapeutic attention.

Keywords: bone mineral density, osteoporosis, systemic tissue diseases, systemic lupus erythematosus.

Published: December 11, 2003  Show citation

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Žurek M, Horák P, Pospíšil Z, Kraina T, Kusá L, Ščudla V. The evaluation of bone mineral density and risk factors of osteoporosis in patients with diffuse connective tissue diseases. Osteologický bulletin. 2003;8(4):125-130.
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