Clin Osteol 2018; 23(1): 6-8

Effects of the gut microbiome on the bone tissue metabolismReview articles

Palička Vladimír

Osteocentrum, Ústav klinické biochemie a diagnostiky, LF v Hradci Králové UK a FN Hradec Králové

The links between different organs and tissues of the human body are multiple and many-sided. Until now, the skeletal system has been considered rather isolated. Recently, the extension of knowledge about the effects of hormones, immunity, nutrition, ions and other factors has considerably advanced. The latest studies demonstrate close relationship between the microbiome, especially the gut microbiome, and bone tissue metabolism. The gut microbiome undoubtedly affects healthy development of bone tissue in childhood and its remodelling in adulthood, absorption of calcium, and production of proinflammatory interleukins including RANKL through influencing the immune system. Estrogen deficiency loosens intercellular junctions of enterocytes and contributes to greater penetration of lipopolysaccharides, toxins and bacteria, and activation of chronic inflammation with a negative effect on bone metabolism. The largest amount of know­ledge has so far come from experimental animal studies, but its considerable part also applies to the human body.


Key words:
mikrobiom -⁠ osteoporosis
Received 30. 8. 2018
Accepted 4. 9. 2018

Keywords: mikrobiom; ⁠ osteoporóza

Received: August 30, 2018; Accepted: September 4, 2018; Published: June 11, 2018  Show citation