Clin Osteol 2013; 18(2): 48-52

Effect of liver regeneration on bone metabolism in adult male Wistar ratsOriginal contributions

K. Doubková, I. Gradoąová, K. ©vejkovská, P. ®ivný,

Objective: The study aimed at d healthy adult male Wistar rats.

Material and methods: Rats were distribute into 5 groups of 8 animals each. The first group were controls with no abdominal surge­ ry. Animals in the second (24LAP) and third (24PH) groups underwent laparotomy and 70% partial hepatectomy, respectively, and were sacrificed 24 hours after the procedure. Animals in groups four (72LAP) and five (72PH) underwent laparotomy and 70% partial he­ patectomy, respectively, and sacrificed 72 hours after the procedure. ELISA was used to determine the bone formation markers pro­ collagen type I N-terminal prope gen (CTx) in the obtained serum.

Results: The 24PH and 72PH groups had nonsignificantly decreased PINP levels as compared with controls; the 72PH group had a sig­ nifican groups.

Conclusion: The results suggest increased bone resorption follo not significant.

Keywords: liver regeneration, partial hepatectomy, bone markers

Published: December 11, 2013  Show citation

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Doubková K, Gradoąová I, ©vejkovská K, ®ivný P. Effect of liver regeneration on bone metabolism in adult male Wistar rats. Osteologický bulletin. 2013;18(2):48-52.
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