Clin Osteol 2021; 26(2): 68-78

Significance and characteristics of selected genes in the pathogenesis of osteoporosisClinical studies

Avuková Buriková Andrea1, Blaščáková Mydlárová Marta1, Poráčová Janka1, Tomková Soňa3, Hricová Katarína1,2, Petrejčíková Eva1
1 Faculty of Humanities and Natural Science, Department of Biology, University of Prešov, Slovakia
2 Department of Internal Medicine, AGEL Hospital Košice-Šaca, a. s., Slovakia
3 Vth Department of Internal Medicine Faculty of Medicine Commenius University and University Hospital Bratislava, Hospital Ružinov, Bratislava, Slovakia

Osteoporosis is a complex disease affected not only by environmental factors but also by a strong genetic component. Genetic factors contribute to osteoporosis by affecting not only bone mineral density but also bone size, quality and bone turnover. However, determining the genetic architecture, and in particular the basic genomic and molecular mechanisms of osteoporosis in vivo in humans, is still challenging. In recent years, we have seen progress in research into the genetic background of osteoporosis in connection with the development of modern methods of molecular biology. Scientific research focuses primarily on the identification and characterization of selected polymorphisms of candidate genes, determining bone quality, bone density (BMD) and, last but not least, the risk of fractures. The results of molecular genetic research on osteoporosis significantly contribute / could contribute to the improvement not only of therapeutic and therapeutic procedures, but especially to the introduction of early prevention in personalized medicine.

Keywords: BMD; fracture risk; gene; osteoporosis; polymorphism; BMD; fracture risk; gene; osteoporosis; polymorphism

Received: January 31, 2021; Accepted: August 27, 2021; Published: December 11, 2021  Show citation

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Buriková Andrea A, Mydlárová Marta B, Poráčová J, Tomková S, Hricová K, Petrejčíková E. Significance and characteristics of selected genes in the pathogenesis of osteoporosis. Clinical Osteology. 2021;26(2):68-78.
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